SARS-CoV-2 coronavirus: serological and smear tests

SARS-CoV-2 coronavirus: serological and smear tests

Two types of tests related to COVID-19 (coronavirus) diagnosis are available on the market. Smear tests confirm active COVID-19 disease.

Serologic tests detect the presence and type of antibodies produced by a person’s immune system after being sick or vaccinated.

Do you have or have had symptoms of an upper respiratory tract viral infection? Have you had contact with a person infected or suspected of being infected with a coronavirus? Do you want to know if you can safely contact others? Want to know if your body has been in contact with the SARS-CoV-2 virus?

Want to know the level of antibodies responsible for immunity?
A significant proportion of infections are sparsely symptomatic or asymptomatic.

Read: Countries need support to vaccinate their highest risk groups

You can perform two types of tests to detect the presence of coronavirus

You can perform smear tests and serological tests (tests for antibodies against coronavirus):

  1. COMBO rapid antigen test detecting the presence of antigens of coronavirus SARS-CoV-2, influenza (A or B strain) or RSV in nasopharyngeal swab, which is equivalent to detecting the presence of infectious virus particles – result available in tens of minutes.
  2. Molecular (genetic) test performed by real time RT-PCR detecting the presence of genetic material of SARS-CoV-2 coronavirus in nasopharyngeal swab.
  3. Antibody panel (semi-quantitative), detecting the presence in the blood of antibodies to coronavirus in the IgM and IgG classes and showing in what concentration they are present.
  4. Anti-S neutralizing antibody test – quantitative measurement of the concentration of neutralizing IgG antibodies specific for the S protein of the SARS-CoV-2 virus spike (spike) – immunity test performed at least 14 days after COVID-19 or after vaccination – test from venous blood, result available within 2-3 days. (Previous name of the test: IgG antibodies quantitative).

What should be done to perform the test?

Detailed information for patients interested in the test:

  • Genetic testing
  • Antibody panel
  • Neutralizing anti-S antibodies (d. quantitative IgG antibodies)

Tests are performed with all procedures to ensure the safety of the test person and medical personnel.

Have you had an illness or vaccination? Would you like to check your antibody levels? Fill out the necessary documents and make an appointment for the test!


  • Timelines for receiving results of tests requiring laboratory analysis (especially RT-PCR tests) depend on the workload of laboratories cooperating with POLMED. Laboratories currently prioritize public sector orders, so the deadline for receiving the result may change.
  • Those performing tests before traveling abroad should independently verify which type of test is accepted in the country of their destination.
  • When performing genetic tests (RT-PCR and antigen tests), one should take into account the risk of receiving an inconclusive result (on the basis of the test, the result of the test cannot be evaluated). In such a situation, the test may need to be repeated.


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